Explore our research publications, including journal articles, conference papers, book chapters, and technical reports.
2024
Single cell and TCR analysis of immune cells from AAV gene therapy-dosed Duchenne muscular dystrophy patients
Emami, M. R., Brimble, M. A., Espinoza, A., Owens, J., Whiteley, L. O., Casinghino, S., Lanz, T. A., Farahat, P. K., Pellegrini, M., Young, C. S., Thomas, P. G., McNally, E. M., Villalta, S. A., Schattgen, S. A., & Spencer, M. J.
Molecular therapy. Methods & clinical development, 32(4), 101349
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice
Fotio, Y., Mabou Tagne, A., Squire, E., Lee, H. L., Phillips, C. M., Chang, K., Ahmed, F., Greenberg, A. S., Villalta, S. A., Scarfone, V. M., Spadoni, G., Mor, M., & Piomelli, D.
Nature communications, 15(1), 1705.
Muscle immune cells protect mitochondrial organelles during exercise
Coulis, G., & Villalta, S. A.
Nature, 625(7993), 35–36.
2023
Dysfunction of the aging female mouse urethra is associated with striated muscle loss and increased fibrosis: an initial report
Sadeghi, Z., Wu, Y. X., Vu, A., Song, L., Phan, W., Kim, J., Keast, J. R., Balis, U., DeLancey, J., Villalta, S. A., & Zi, X.
American journal of clinical and experimental urology, 11(6), 516–529.
Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
Torre D, Fstkchyan YS, Ho JSY, Cheon Y, Patel RS, Degrace EJ, Mzoughi S, Schwarz M, Mohammed K, Seo JS, Romero-Bueno R, Demircioglu D, Hasson D, Tang W, Mahajani SU, Campisi L, Zheng S, Song WS, Wang YC, Shah H, Francoeur N, Soto J, Salfati Z, Weirauch MT, Warburton P, Beaumont K, Smith ML, Mulder L, Villalta SA, Kessenbrock K, Jang C, Lee D, De Rubeis S, Cobos I, Tam O, Hammell MG, Seldin M, Shi Y, Basu U, Sebastiano V, Byun M, Sebra R, Rosenberg BR, Benner C, Guccione E, Marazzi I.
Mol Cell. 2023 Dec 7;83(23):4255-4271.e9.
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodríguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA.
Mol Cell. 2023 Dec 7;83(23):4255-4271.e9.
Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy
Emami MR, Espinoza A, Young CS, Ma F, Farahat PK, Felgner PL, Chamberlain JS, Xu X, Pyle AD, Pellegrini M, Villalta SA, Spencer MJ.
Mol Ther Methods Clin Dev. 2023 Jun 12;30:90-102.
A cellular and molecular spatial atlas of dystrophic muscle
Stec MJ, Su Q, Adler C, Zhang L, Golann DR, Khan NP, Panagis L, Villalta SA, Ni M, Wei Y, Walls JR, Murphy AJ, Yancopoulos GD, Atwal GS, Kleiner S, Halasz G, Sleeman MW.
Proc Natl Acad Sci U S A. 2023 Jul 18;120(29)
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt JM, Farahat PK, Nguyen Q, Pervolarakis N, McLinden K, Thurlow L, Movahedi S, Hughes BS, Duarte J, Sorn A, Montoya E, Mozaffar I, Dragan M, Othy S, Joshi T, Hans CP, Kimonis V, MacLean AL, Nie Q, Wallace LM, Harper SQ, Mozaffar T, Hogarth MW, Bhattacharya S, Jaiswal JK, Golann DR, Su Q, Kessenbrock K, Stec M, Spencer MJ, Zamudio JR, Villalta SA.
Sci Adv. 2023 Jul 7;9(27)
2022
Correlations of disease severity outcome measures in inclusion body myositis
Goyal NA, Greenberg SA, Cauchi J, Araujo N, Li V, Wencel M, Irani T, Wang LH, Palma AM, Villalta SA, Mozaffar T.
Neuromuscul Disord. 2022 Oct;32(10):800-805
Next-Generation SINE Compound KPT-8602 Ameliorates Dystrophic Pathology in Zebrafish and Mouse Models of DMD
English KG, Reid AL, Samani A, Coulis GJF, Villalta SA, Walker CJ, Tamir S, Alexander MS.
Biomedicines. 2022 Sep 26;10(10)
Immunophenotyping of Inclusion Body Myositis Blood T and NK Cells
Goyal NA, Coulis G, Duarte J, Farahat PK, Mannaa AH, Cauchii J, Irani T, Araujo N, Wang L, Wencel M, Li V, Zhang L, Greenberg SA, Mozaffar T, Villalta SA.
Neurology. 2022 Mar 29;98(13)
Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation
Dragan M, Sun P, Chen Z, Ma X, Vu R, Shi Y, Villalta SA, Dai X.
J Invest Dermatol. 2022 Mar;142(3 Pt A)
Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis
Britson, K. A., Ling, J. P., Braunstein, K. E., Montagne, J. M., Kastenschmidt, J. M., Wilson, A., Ikenaga, C., Tsao, W., Pinal-Fernandez, I., Russell, K. A., Reed, N., Mozaffar, T., Wagner, K. R., Ostrow, L. W., Corse, A. M., Mammen, A. L., Villalta, S. A., Larman, H. B., Wong, P. C., & Lloyd, T. E.
Science translational medicine, 14(628)
2021
Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation
Mohammadi, M. R., Rodriguez, S. M., Luong, J. C., Li, S., Cao, R., Alshetaiwi, H., Lau, H., Davtyan, H., Jones, M. B., Jafari, M., Kessenbrock, K., Villalta, S. A., de Vos, P., Zhao, W., & Lakey, J. R. T.
Communications biology, 4(1), 685.
A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression
Kastenschmidt, J. M., Coulis, G., Farahat, P. K., Pham, P., Rios, R., Cristal, T. T., Mannaa, A. H., Ayer, R. E., Yahia, R., Deshpande, A. A., Hughes, B. S., Savage, A. K., Giesige, C. R., Harper, S. Q., Locksley, R. M., Mozaffar, T., & Villalta, S. A.
Cell reports, 35(2), 108997.
2020
The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice
Hightower, R. M., Reid, A. L., Gibbs, D. E., Wang, Y., Widrick, J. J., Kunkel, L. M., Kastenschmidt, J. M., Villalta, S. A., van Groen, T., Chang, H., Gornisiewicz, S., Landesman, Y., Tamir, S., & Alexander, M. S.
Molecular therapy : the journal of the American Society of Gene Therapy, 28(1), 189–201.
2019
QuantiMus: A Machine Learning-Based Approach for High Precision Analysis of Skeletal Muscle Morphology
Kastenschmidt, J. M., Ellefsen, K. L., Mannaa, A. H., Giebel, J. J., Yahia, R., Ayer, R. E., Pham, P., Rios, R., Vetrone, S. A., Mozaffar, T., & Villalta, S. A.
Frontiers in physiology, 10, 1416.
2018
Characterization of the Inflammatory Response in Dystrophic Muscle Using Flow Cytometry
Kastenschmidt, J. M., Avetyan, I., & Villalta, S. A.
Methods in molecular biology (Clifton, N.J.), 1687, 43–56.
2017
Identification of IL-40, a Novel B Cell-Associated Cytokine
Catalan-Dibene, J., Vazquez, M. I., Luu, V. P., Nuccio, S. P., Karimzadeh, A., Kastenschmidt, J. M., Villalta, S. A., Ushach, I., Pone, E. J., Casali, P., Raffatellu, M., Burkhardt, A. M., Hernandez-Ruiz, M., Heller, G., Hevezi, P. A., & Zlotnik, A.
Journal of immunology (Baltimore, Md. : 1950), 199(9), 3326–3335.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Morita, S., Villalta, S. A., Feldman, H. C., Register, A. C., Rosenthal, W., Hoffmann-Petersen, I. T., Mehdizadeh, M., Ghosh, R., Wang, L., Colon-Negron, K., Meza-Acevedo, R., Backes, B. J., Maly, D. J., Bluestone, J. A., & Papa, F. R.
Cell metabolism, 25(5), 1207.
2016
FOXO1 Mediates Vitamin D Deficiency-Induced Insulin Resistance in Skeletal Muscle
Chen, S., Villalta, S. A., & Agrawal, D. K.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 31(3), 585–595.
2015
Immune-mediated pathology in Duchenne muscular dystrophy
Rosenberg, A. S., Puig, M., Nagaraju, K., Hoffman, E. P., Villalta, S. A., Rao, V. A., Wakefield, L. M., & Woodcock, J.
Science translational medicine, 7(299), 299rv4.
The immune system in Duchenne muscular dystrophy: Friend or foe
Villalta, S. A., Rosenberg, A. S., & Bluestone, J. A.
Rare diseases (Austin, Tex.), 3(1)
Prior to 2015
Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy
Villalta, S. A., Rosenthal, W., Martinez, L., Kaur, A., Sparwasser, T., Tidball, J. G., Margeta, M., Spencer, M. J., & Bluestone, J. A.
Science translational medicine, 6(258), 258ra142.
Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function
Villalta, S. A., Lang, J., Kubeck, S., Kabre, B., Szot, G. L., Calderon, B., Wasserfall, C., Atkinson, M. A., Brekken, R. A., Pullen, N., Arch, R. H., & Bluestone, J. A.
Diabetes, 62(8), 2870–2878.
IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration
Deng, B., Wehling-Henricks, M., Villalta, S. A., Wang, Y., & Tidball, J. G.
Journal of immunology (Baltimore, Md. : 1950), 189(7), 3669–3680.
IFN-γ promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation
Villalta, S. A., Deng, B., Rinaldi, C., Wehling-Henricks, M., & Tidball, J. G.
Journal of immunology (Baltimore, Md. : 1950), 187(10), 5419–5428.
Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype
Villalta, S. A., Rinaldi, C., Deng, B., Liu, G., Fedor, B., & Tidball, J. G.
Human molecular genetics, 20(4), 790–805.
Regulatory interactions between muscle and the immune system during muscle regeneration
Tidball, J. G., & Villalta, S. A.
American journal of physiology. Regulatory, integrative and comparative physiology, 298(5), R1173–R1187.
NO may prompt calcium leakage in dystrophic muscle
Tidball, J. G., & Villalta, S. A.
Nature medicine, 15(3), 243–244.
Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy
Villalta, S. A., Nguyen, H. X., Deng, B., Gotoh, T., & Tidball, J. G.
Human molecular genetics, 18(3), 482–496.
Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing
Sutherland, R. E., Olsen, J. S., McKinstry, A., Villalta, S. A., & Wolters, P. J.
Journal of immunology (Baltimore, Md. : 1950), 181(8), 5598–5605.
Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy
Wehling-Henricks, M., Sokolow, S., Lee, J. J., Myung, K. H., Villalta, S. A., & Tidball, J. G.
Human molecular genetics, 17(15), 2280–2292.
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
Acharyya, S., Villalta, S. A., Bakkar, N., Bupha-Intr, T., Janssen, P. M., Carathers, M., Li, Z. W., Beg, A. A., Ghosh, S., Sahenk, Z., Weinstein, M., Gardner, K. L., Rafael-Fortney, J. A., Karin, M., Tidball, J. G., Baldwin, A. S., & Guttridge, D. C.
The Journal of clinical investigation, 117(4), 889–901.
Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice
Wolters, P. J., Mallen-St Clair, J., Lewis, C. C., Villalta, S. A., Baluk, P., Erle, D. J., & Caughey, G. H.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 35(1), 82–88.
Mast cell dipeptidyl peptidase I mediates survival from sepsis
Mallen-St Clair, J., Pham, C. T., Villalta, S. A., Caughey, G. H., & Wolters, P. J.
The Journal of clinical investigation, 113(4), 628–634.