Human Studies

1. Single-cell transcriptomic approaches for defining the role of the immune system in inclusion body myositis

   Translational studies are essential in transforming laboratory findings into novel therapies that positively impact patient health and disease outcomes. In collaboration with our colleagues in the Muscle Biology and Disease Working Group, we are using scRNAseq profiling of immune cells from inclusion body myositis (IBM) patients to define the mechanisms that promote immunological dysfunction in these patients. In addition to gene expression studies, we are profiling the T cell receptor repertoire at single-cell resolution for future antigen discovery effort.

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